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We succeeded to establish the laboratory of Process Analytical Technology (VAN STADEN PATLAB) as a laboratory of excellence in Bucharest, Romania with international standards that is recognized not only in Europe, but also among the worldwide scientific community. This is evident from the research output (dissemination) of the laboratory given below:-

 

PEER REVIEWED INTERNATIONAL PUBLICATIONS

 

2008

 

1.         Sequential injection analysis utilizing amperometric biosensors as detectors for simultaneous determination of L- and D-pipecolic acid.

           R.I. Stefan-van Staden, R. M. Nejem, J.F. van Staden and H.Y. Aboul-Enein.

           Instrumentation Science and Technology, 36 (5) (2008) 355 - 368.

 

2.         Determination of (+)-3,3’,5,5’-tetraiodo (L-T4) in serum and in pharmaceutical formulations using a sequential injection

           analysis/immunosensor system.

           R.I. Stefan-van Staden, J.F. van Staden, H.Y. Aboul-Enein, M. C. Mirica, I. Balcu and N. Mirica.

          Journal of Immunoassay and Immunochemistry, 29 (4) (2008) 348 - 355.

 

2009

 

1.         Enantioanalysis of L-proline using C60 as chiral selectors.

            R.I. Stefan-van Staden.

            Analytical Letters, 42 (2) (2009) 323-329.

 

2.         Amperometric immunosensors for the determination of 2’,3’-dideoxyinosine

            R.I. Stefan-van Staden and K.I. Ozoemena

            Analytical Letters, 42 (4) (2009) 758-763.

 

3.         Enantioanalysis of S-Ketoprofen using enantioselective, potentiometric membrane electrodes.

            R.I. Stefan-van Staden, N. S. Nhlapo, J.F. van Staden and H.Y. Aboul-Enein.

            Analytical Letters, 42 (5) (2009) 764 - 774.

 

4.         Macrocyclic antibiotics as chiral selectors in the design of enantioselective, potentiometric membrane electrodes for the determination of

            S-flurbiprofen.

            R.I. Stefan-van Staden, J.F. van Staden and H.Y. Aboul-Enein.

            Analytical and Bioanalytical Chemistry, 394 (3) (2009) 821-826.

 

5.         Utilization of an enantioselective surface plasmon resonance electrode for the selection of the best C70 fullerene as chiral selector for the

            enantioanalysis of L-cysteine

            R.I. Stefan-van Staden, L. Holo

            Preparative Biochemistry and Biotechnology, 39 (2) (2009) 142-146.

 

6.         Metallophthalocyanine based carbon paste electrodes for the determination of 2’,3’-dideoxyinosine

            K.I. Ozoemena, R.I. Stefan-van Staden and T. Nyokong

            Electroanalysis, 21 (14) (2009) 1651-1654.

 

7.         Enantioselective determination of R-Clenbuterol using an enantioselective, potentiometric membrane electrode based on a β-cyclodextrin

           derivative.

           R.I. Stefan-van Staden, L. Holo, B Moeketsi, J.F. van Staden and H.Y. Aboul-Enein.

           Instrumentation Science and Technology, 37 (2) (2009) 189 - 196.

 

8.         Determination of (S)-(+)-Ibuprofen using enantioselective, potentiometric membrane electrodes based on a Macrocyclic Antibiotics.

            R.I. Stefan-van Staden, T. Mashile, K. C. Mathabathe and J.F. van Staden.

            Instrumentation Science and Technology, 37 (2) (2009) 197 - 203.

 

9.         Enantioanalysis of butaclamol using enantioselective, potentiometric electrodes.

            R.I. Stefan-van Staden, R.G. Bokretsion, J.F. van Staden and H.Y. Aboul-Enein.

           Analytical Letters, 42 (8) (2009) 1111 - 1118.

 

10.       Maltodextrins as chiral selectors in biomedical enantioanalysis. A minireview.

           R.I. Stefan-van Staden, J.F. van Staden, H.Y. Aboul-Enein, M.C. Mirica, M. Iorga and I. Balcu

           The Open Chem Biomed Meth J , 2 (2009) 107-110.

 

2010

 

1.         Application of porphyrins in flow-injection analysis. A Review

           J.F. van Staden and R.I. Stefan-van Staden.

            Talanta, 80 (5) (2010) 1598 – 1605.

 

2.         Enantioanalysis of S-deprenyl based on its interaction with C60 fullerene derivatives.

            R.I. Stefan-van Staden.

            Electrochimica Acta, 55 (5) (2010) 1772 - 1777.

 

3.         Enantioanalysis of S-Ibuprofen using [5-6] Fullerene-C70 and diethyl (1,2-methanofullerene C70)-71-71-dicarboxylate.

            R.I. Stefan-van Staden.

           Analytical Methods, 2 (1) (2010) 37 – 40.

 

4.         Diamond paste based electrodes for the determination of  sildenafil citrate (viagra).       

           R.I. Stefan-van Staden, J.F. van Staden and H.Y. Aboul-Enein.

          Journal of Solid State Electrochemistry, 14 (6) (2010) 997 – 1000

 

5.         Enantioanalysis of R-deprenyl based on its molecular interaction with C70 fullerenes.

            R.I. Stefan-van Staden

            Talanta, 81 (3) (2010) 865 - 870

 

6.         Determination of free L-T4 and free L-T3 from blood using the immunosensors/sequential injection analysis system.

            R.I. Stefan, J.F. van Staden, H.Y. Aboul-Enein, I. Balcu, M.C. Mirica, G.L. Radu,

            Analytical Letters, 43 (7-8) (2010) 1119 – 1125.

 

7.         Micro- and nanosensors. Recent developments and features. A minireview.

            R.I. Stefan-van Staden, J.F. van Staden, S.C. Balasoiu, O.R. Vasile

           Analytical Letters, 43 (7-8) (2010) 1111 - 1118.

 

8.         Simultaneous determination of L- and D-T4 using a sequential injection  analysis/sensors system.

            R.I. Stefan-van Staden, J.F. van Staden, H.Y. Aboul-Enein, I. Balcu, M.C. Mirica

            Combinatorial Chemistry & High Throughput Screening, 13 (6) (2010) 497 - 501.

 

9.         Enantioanalysis of (-)butaclamol using vancomycin and teicoplanin as chiral selectors.

            R.I. Stefan-van Staden, N.S. Nhlapo, J.F. van Staden, H.Y. Aboul-Enein.

            Combinatorial Chemistry & High Throughput Screening, 13 (8) (2010) 690 – 693.

 

10.       Wireless electrochemical sensors. A tool for process control. The past, present and the future. A mini-review.

            J.F. van Staden, R.I. Stefan-van Staden, S.C. Balasoiu.

            Critical Reviews in Analytical Chemistry, 40 (4) (2010) 226 -233..

 

11.       Enantioanalysis of D-histidine based on its interaction with [5-6] fullerene-C70 and diethyl (1,2-methanofullerene C70)-71-71-

            dicarboxylate.

            R.I. Stefan-van Staden.

            New Journal of Chemistry, 34 (6) (2010) 1141 – 1147.

 

12.       Diamond paste based electrodes for the determination of Ag(I).

            R.I. Stefan-van Staden, S. G. Bairu and J. F. van Staden.

            Analytical Methods, 2 (6) (2010) 250 - 252.

 

13.       Carbon and diamond paste microelectrodes based on Mn(III) porphyrins for the determination of dopamine.

            S. C. Balasoiu, R.I. Stefan-van Staden, J. F. van Staden, S. Pruneanu and G. L. Radu.

            Analytica Chimica Acta, 668 (2) (2010) 201 - 207.

 

  

2011

 

1.         Enantioselective potentiometric membrane electrodes based on antibiotics for the determination of

            L-  and D-Glyceric Acids.

            R.I. Stefan-van Staden, R. M. Nejem, J.F. van Staden and H.Y. Aboul-Enein

            Current Pharmaceutical Analysis, 7 (4) (2011) 253-257.

 

2.         Enantioanalysis of L-histidine using enantioselective, potentiometric membrane electrodes based

            on maltodextrins

            R.I. Stefan-van Staden, L. Holo

            Anal.Lett.,44 (6) (2011) 968-975.

 

3.         Cyclodextrins based enantioselective, potentiometric membrane electrodes (EPME) and their

            applications for enantioanalysis of L-Cysteine in urine.

            R.I. Stefan-van Staden, L. Holo and J.F. van Staden

            Current Pharmaceutical Analysis, 7 (4) (2011) 258-261.

 

4.         Disposable stochastic dot sensors for the assay of ascorbic acid in pharmaceutical samples, beverages

            and biological fluids.

R.I. Stefan-van Staden, J.F. van Staden and S.C. Balasoiu

            Analytical Letters, 43 (13) (2011) 2280-2286.

 

5.         Amperometric dot-sensors based on Zinc porphyrins for the Sildenafil citrate determination.

S.C. Balasoiu, R.I. Stefan-van Staden, J.F. van Staden, R.M. Ion, G.L. Radu and H.Y. Aboul-Enein

            Electrochimica Acta, 58 (1) (2011) 290-295.

 

6.         Enantioselective, potentiometric membrane electrodes based on antibiotics for the determination of

            L- and D-glyceric acids.

            R.I. Stefan-van Staden, R.M. Nejem, J.F. van Staden and H.Y. Aboul-Enein

            International Journal of Electrochemistry, Volume 2011, Article ID427238, 4pg,doi:10.4061/2011/427238.

 

2012

 

1.         Determination of L- and D-Fucose Using Amperometric Electrodes Based on Diamond Paste.

            R.I. Stefan-van Staden, R. M. Nejem, J.F. van Staden and H.Y. Aboul-Enein

            Analyst, 137(4) (2012) 903 - 909.

 

2.         Amperometric biosensor based on diamond paste for the enantioanalysis of l-lysine.

            R.I. Stefan-van Staden, R. M. Nejem, J.F. van Staden and H.Y. Aboul-Enein

            Biosensors and Bioelectronics, 35(2) (2012) 439-442.

 

3.         A new sensor for the assay of breast cancer antigen.

R.I. Stefan-van Staden, I. Stefanescu, J.F. van Staden and M. Enachescu.

            Analyst, xx (xx) (2012) In Press.

 

4.         Microelectrodes based on porphyrins for the determination of ascorbic acid in pharmaceutical

            samples and beverages.

R.I. Stefan-van Staden, S.C. Balasoiu, J.F. van Staden and G.L. Radu.

            Journal of Porphyrins and Phthalocyanines, xx (xx) (2012) In Press.

 

5.         Flow-injection analysis systems with different detection devices and other related

            techniques for the in vivo and in vitro determination of dopamine as neurotransmitter.

            A review.

            J.F. van Staden and R.I. Stefan-van Staden.

            Talanta, xx (xx) (2012) In Press.

 

 

  

INTERNATIONAL CONFERENCE CONTRIBUTIONS

 

2008

 

ORAL

 

1.         Fullerenes – New Chiral selectors for enantioanalysis.

            R.I. Stefan-van Staden.

            International Conference on Chemistry and Chemical Engineering. Romanian Chemical Society, Politehnica University

           of Timisoara, Timisoara, Romania. 28 – 30 May 2008.

 

2.         PATLAB. From test tube to Process Systems. The road ahead.

            J.F. van Staden.

            International Conference on Chemistry and Chemical Engineering. Romanian Chemical Society, Politehnica University of

            Timisoara, Timisoara, Romania. 28 – 30 May 2008.

 

3.         The importance and essentiality of real-time intelligent interactive monitoring and control in medical, pharmaceutical and clinical fields with

            PAT.

           J.F. van Staden, R.I. Stefan-van Staden and I. Balcu.

           3rd International Conference on Biomaterials and Medical Devices, BIOMMEDD’2008, Romanian and European Society

            for Biomaterials, Politehnica University of Bucharest, Romania. 13 – 16 November 2008.

 

4.         New nanostructured materials based on porphyrins for the design of stochastic sensors.

            R.I. Stefan-van Staden, E. Fagadar-Cosma, J.F. van Staden, O. Radacina and S. Balasoiu.

            3rd International Conference on Biomaterials and Medical Devices, BIOMMEDD’2008, Romanian and European

            Society for Biomaterials, Politehnica University of Bucharest, Romania. 13 – 16 November 2008.

 

2009

 

ORAL

 

1.         Nanostructured glasses and powders based on hybrid silica materials incorporating 5,10,15-tris(3-hydroxy-phenyl)-20-(3,4-dimethoxy-

            phenyl)-porphyrin

            E. Fagadar-Cosma, C. Enache, D. Vlascici, Gh. Fagadar-Cosma, R.I. Stefan-van Staden, H. Stadler, J.F. van Staden.

            Nanotech Insight, 29th March – 2nd April 2009, Barcelona, Spain.

  

2.         Determination of free-L-T3 and free-L-T4 from blood using the immunosensors/sequential injection analysis system.

           R.I. van Staden, J.F. van Staden, H.Y. Aboul-Enein, G.L. Radu, N. Mirica, I. Balcu, M.C. Mirica.

           Journées d’Electrochimie XIV-čme édition, 6 - 10 July 2009, Sinaia, Romania.

 

3.         Flow- or Non Flow-based, Unit operations, Micro- or/and Nanosensors: "Microfluidics", Real-time: Is a marriage with PAT always

            possible? The Reality and the Future.

            JF van Staden.

           Euroanalysis XV, Division of Analytical Chemistry (DAC) of the European Association of Chemical and Molecular

           Sciences (EuCheMS) and the Austrian Society for Analytical Chemistry (ASAC),  Innsbruck, Austria, 6 - 10 September 2009.

 

4.         New stochastic microsensors based on nanostructured materials for molecular diagnosis.

            R.I. van Staden

            Euroanalysis XV, Division of Analytical Chemistry (DAC) of the European Association of Chemical and Molecular Sciences

            (EuCheMS) and the Austrian Society for Analytical Chemistry (ASAC),  Innsbruck, Austria, 6 - 10 September 2009.
 

5.         Porphyrins in flow injection analysis

            J. F. van Staden

             IMA’2009. The 6th International Conference of  Instrumental Methods of Analysis. Modern Trends and Applications.

            Athens, Greece, 4 - 8 October 2009.

 

6.         New stochastic microsensors based on nanostructured manganese porphyrins for molecular diagnosis

            R. I. van Staden

            IMA’2009. The 6th International Conference of  Instrumental Methods of Analysis. Modern Trends and Applications.

           Athens, Greece, 4 - 8 October 2009.

 

7.         Sensors and biosensors for multicomponent analysis using flow systems

            J.F. van Staden, R. I. van Staden

           Modern Analytical Methods 2009 (dedicated to the 50th Anniversary of Nobel Prize in Polarography, J Heyrowsky). Prague,

           Czech Republic. 9 - 13 December 2009.

 

POSTERS

 

1.         Porphyrins as new nanostructured materials for the design of stochastic sensors.

            R.I. Stefan-van Staden, E. Fagadar-Cosma, O. Radacina,  J.F. van Staden, S. Balasoiu, I. Balcu, M. Iorga.

            Nanotech Insight, 29th March – 2nd April 2009, Barcelona, Spain.

 

2.         Enantioanalysis of (-)butaclamol using vancomycin and teicopplanin as chiral selectors

            R.I. van Staden, J.F. van Staden, H.Y. Aboul-Enein, N. Mirica

            Euroanalysis XV, Division of Analytical Chemistry (DAC) of the European Association of Chemical and Molecular Sciences

            (EuCheMS) and the Austrian Society for Analytical Chemistry (ASAC),  Innsbruck, Austria, 6 - 10 September 2009.

 

3.         Modified diamond paste microelectrodes for the assay of ascorbic acid

            R.I. van Staden, S.C. Balasoiu, O.R. Vasile, J.F. van Staden, G.L. Radu

            Euroanalysis XV, Division of Analytical Chemistry (DAC) of the European Association of Chemical and Molecular Sciences

           (EuCheMS) and the Austrian Society for Analytical Chemistry (ASAC),  Innsbruck, Austria, 6 - 10 September 2009.

 

4.         Modified diamond paste microsensors for the assay of dopamine

            R.I. van Staden, S.C. Balasoiu, O.R. Vasile, J.F. van Staden, G.L. Radu

            IMA’2009. The 6th International Conference of  Instrumental Methods of Analysis. Modern Trends and Applications.

            Athens, Greece, 4 - 8 October 2009.

 

5.         Wireless sensors a tool for process control

            J.F. van Staden, R.I. van Staden, S.C. Balasoiu, O.R. Vasile,

            IMA’2009. The 6th International Conference of  Instrumental Methods of Analysis. Modern Trends and Applications.

           Athens, Greece, 4 - 8 October 2009.

 

6.         New nanostructured materials based electrochemical microsensors

            O.R. Vasile, R.I. van Staden, J.F. van Staden, S.C. Balasoiu, B.S. Vasile

            TNT 2009. 7-11 September, 2009 , Barcelona, Spain.

 

 

2010

 

ORAL

 

KEYNOTE PLENARY LECTURES

 

1.         The Importance and essentiality of interactive real-time intelligent monitoring and control in food processing and distribution with PAT

            with food processing and distribution.

             J. F. van Staden.

            Challenges in Food Chemistry, Workshop, 28th May – 29th May 2010,    Constanta, Romania.

 

2.         Stochastic sensors - a new tool for Food Analysis.

            R. I. van Staden.

            Challenges in Food Chemistry, Workshop, 28th May – 29th May 2010, Constanta, Romania.

 

3.         Stochastic Microsensors for Molecular Diagnosis.

            R. I. van Staden.

            IMCS’13, 13th International Meeting on Chemical Sensors, 11 – 14 July 2010, Perth, Australia.

 

4.         THE EVOLUTION OF ANALYTICAL CHEMISTRY FROM MANUAL PROCEDURES IN

            ROUTINE LABORATORIES TO FULLY AUTOMATED    REAL-TIME INTERACTIVE MICRO

            INFORMATION MANAGEMENT AND PROCESS CONTROL ON-SITE SYSTEMS.

            Prof Dr J. F. (Koos) van Staden.

            CMEQF 01-2010, Control and Metrology of Environmental Quality Factors, 23 – 27 November 2010, Iasi, Romania.

 

 

LECTURES

 

1.         DOT Sensors – New Tools for Biomedical Analysis.

            J. F. van Staden and R.I. Stefan-van Staden.

            IMCS’13, 13th International Meeting on Chemical Sensors, 11 – 14 July 2010, Perth, Australia.

 

2.         Carbon and Diamond Paste Microelectrodes based on Mn(III) Porphyrins for the Determination of Dopamine.

           J.F. van Staden, R.I. Stefan-van Staden, S.C. Balasoiu, and G.L. Radu.

           IMCS’13, 13th International Meeting on Chemical Sensors, 11 – 14 July 2010, Perth, Australia.

 

3.         DOT Sensors.

            J. F. van Staden.

            Diaspora Conference, 22nd – 24th September 2010, Bucharest, Romania.

 

4.         Diamond Paste based electrochemical (Bio)sensors.

            R. I. van Staden.

            Diaspora Conference, 22nd – 24th September 2010, Bucharest, Romania.

 

5.         COMBINED DOT SENSORS FOR FOOD ANALYSIS.

          J. F. van Staden and R. I. van Staden.

            AACD 2010, 7th Aegean Analytical Chemistry Days, 29th September – 3rd October 2010, Lesvos, Greece.

 

6.         MINICELLS FOR BIOMEDICAL INVESTIGATIONS.

            R. I. van Staden and J. F. van Staden.

            AACD 2010, 7th Aegean Analytical Chemistry Days, 29th September – 3rd October 2010, Lesvos, Greece.

 

POSTER

 

1.         Modified Carbon Paste Electrodes based on Porphyrin for the Enantioanalysis of S-Captopril.

            S. Balasoiu, R.I. van Staden, J.F. van Staden and G. L. Radu.

            Nanomeasures2010, 3rd – 4th June 2010, Krakow, Poland.

 

 

2011

 

ORAL

 

INVITED LECTURES

 

1.         Nanotechnology and flow systems.

J F van Staden.

            ICFIA=2011. 17th International Conference on Flow Injection Analysis, including related

            techniques. Krakow, Poland. 3-8 July 2011.

 

LECTURES

 

1.         Nanotechnology in the flow domain of Process Analysis.

            J.F. van Staden, R.I. van Staden.

            Euroanalysis XVI, Division of Analytical Chemistry (DAC) of the European Association

            of Chemical and Molecular Sciences (EuCheMS) and the Austrian Society for

            Analytical Chemistry (ASAC),  Belgrade, Serbia, 11 - 15 September 2011.

 

POSTERS

 

1.         Enantioanalysis of Pipecolic acid with stochastic and potentiometric microsensors.

            RI Stefan-van Staden, I Moldoveanu, DF Sava, C Kapnissi-Christodoulou,

            JF van Staden.

            Euroanalysis XVI, Division of Analytical Chemistry (DAC) of the European Association

            of Chemical and Molecular Sciences (EuCheMS) and the Austrian Society for

            Analytical Chemistry (ASAC),  Belgrade, Serbia, 11 - 15 September 2011.

 

2.         Amperometric Dot-sensors Based on Zinc Porphyrins for Sildenafil Citrate Determination.

            S. Balasoiu, R.I. van Staden, J.F. van Staden and G. L. Radu.

            Euroanalysis XVI, Division of Analytical Chemistry (DAC) of the European Association

            of Chemical and Molecular Sciences (EuCheMS) and the Austrian Society for

            Analytical Chemistry (ASAC),  Belgrade, Serbia, 11 - 15 September 2011.

 

2012

 

ORAL

 

LECTURES

 

1.         Amperometric Dot-sensors Based on Zinc Porphyrins for Sildenafil Citrate Determination.

            J. F. van Staden and R.I. Stefan-van Staden.

            IMCS’14, 14th International Meeting on Chemical Sensors, 20-23 May 2012, Nuremberg,

            Germany.

PATENTS

 

2009

 

1.         STOC-µSENS-CMD

Raluca-Ioana van Staden, Jacobus Frederick van Staden

 

EARLY DETECTION OF CANCER –TIME IS LIFE.

 

Website link:  http://vimeo.com/38098247

 

 

 

 

 

 

AWARDS

 

2008

 

NATIONAL

 

1.         Raluca-Ioana van Staden. Gold Medal and Diploma of Excellence ((with the contribution of Dr Eugenia-Lenuta Fagadar-Cosma (Institute of Chemistry Timisoara) regarding the supplying of the porphyrins for the design of the sensors on Contract nr D1 1055/2007)) for a patent on stochastic sensors at the 2nd International Congress of the Researchers and Inventors from Romania, 11 - 12 December 2008, Bucharest, Romania.

 

2009

 

1.         Raluca-Ioana van Staden was awarded the Second (2nd) Prize in a Gala of Prizes for Education, Section Research, on 29 October 2009 in Bucharest, Romania organized by the Foundation Dinu Patriciu.

 

NATIONAL

 

1.         Raluca-Ioana van Staden. Pro Invent Medal and Diploma of Excellence, and Diploma of Excellence of the Society of Inventors from Romania, ((with the contribution of Dr Eugenia-Lenuta Fagadar-Cosma (Institute of Chemistry Timisoara) regarding the supplying of the porphyrins for the design of the sensors on Contract nr D1 1055/2007)) for a patent on stochastic sensors at the Pro Invent, 24 - 27 March 2009, Cluj-Napoca, Romania.

 

2.         Raluca-Ioana van Staden and Jacobus Frederick van Staden: Gold Medal and Award Extraordinary Recognition of the Union of Croatian Innovators for a patent with title:STOC-µSENS-CMD”regarding cancer diagnosis at molecular level, before the patient is clinically ill, at Inventika, 28 - 31 October 2009, Bucharest, Romania.

 

INTERNATIONAL

 

1.         Raluca-Ioana van Staden. Gold Medal, and Arca Prize of the Society of Inventors from Croatia, ((with the contribution of Dr Eugenia-Lenuta Fagadar-Cosma (Institute of Chemistry Timisoara) regarding the supplying of the porphyrins for the design of the sensors on Contract nr D1 1055/2007)) for a patent on stochastic sensors at the 37eme Salon International des Inventions des Techniques et Produit Nouveaux, 1-5 April 2009, Geneve, Switzerland.

 

2.         Raluca-Ioana van Staden. Gold Medal, and the Prize of the Polish Federation of Engineering Association - NOT, ((with the contribution of Dr Eugenia-Lenuta Fagadar-Cosma (Institute of Chemistry Timisoara) regarding the supplying of the porphyrins for the design of the sensors on Contract nr D1 1055/2007)) for a patent on stochastic sensors at the International Warsaw Invention Show, IWIS 2009, 1-3 June 2009, Warsaw, Poland.

 

3.         Raluca-Ioana van Staden and Jacobus Frederick van Staden: Gold Medal and Premiul Technopol Moscova for a patent with title:STOC-µSENS-CMD”regarding cancer diagnosis at molecular level, before the patient is clinically ill, at the IXth Moscow International Salon of Innovations and Investments, 26 - 29 August 2009,  Moscow, Russian Federation.

 

4.         Raluca-Ioana van Staden and Jacobus Frederick van Staden: Silver Bord for the patent with the title:STOC-µSENS-CMD”regarding cancer diagnosis at molecular level, before the patient is clinically ill, at ARCA 2009, 15-19 September 2009, Zagreb, Croatia

 

5.         Raluca-Ioana van Staden and Jacobus Frederick van Staden: Gold Medal with mention and AGEPI Cup of the Agency of the Intelectual Property from Moldova for the patent:STOC-µSENS-CMD”regarding cancer diagnosis at molecular level, before the patient is clinically ill, at EUREKA 2009, 19-21 November 2009,  Brussels, Belgium.

 

2010

 

NATIONAL

 

 

1.         Raluca-Ioana van Staden and Jacobus Frederick van Staden: Gold Medal with special mention and Diploma of Excellence for the patent:STOC-µSENS-CMD”regarding cancer diagnosis at molecular level, before the patient is clinically ill, at PRO INVENT 2010, 16-19 March 2010, Cluj-Napoca, Romania.

 

2.         Prof Dr Jacobus Frederick van Staden: Gold Medal and Diploma for the Exceptional Contribution at the International PRO INVENT 2010, 16-19 March 2010,  Cluj-Napoca, Romania.

 

INTERNATIONAL

 

1.         Raluca-Ioana van Staden was awarded the top Geneva Gold Trophy from the World Intellectual Property Organization as the best "Best Woman Inventor" for the patent:STOC-µSENS-CMD” – Raluca-Ioana van Staden and Jacobus Frederick van Staden regarding microsensors for cancer diagnosis at molecular level in 6 minutes, before the patient is clinically ill, 38eme Salon International des Inventions des Techniques et Produit Nouveaux, 20-25 April 2010, Geneve, Switzerland.

 

2.         Raluca-Ioana van Staden and Jacobus Frederick van Staden were awarded the Gold Medal with special mention and Diploma of Excellence with special congratulations from the Jury as well as a special prize in the form of the L’AGEPI medal and diploma from the Republic of Moldova for the patent:STOC-µSENS-CMD”regarding microsensors for cancer diagnosis at molecular level in 6 minutes, before the patient is clinically ill, 38eme Salon International des Inventions des Techniques et Produit Nouveaux, 20-25 April 2010, Geneve, Switzerland.

 

 

PATLAB also fulfil its mission with a steadily increase in the number of post graduate (Doctorand) students and currently 4 students are busy with research for PhD at PATLAB, 2 from the POLITEHNICA  University of Bucharest and 2 from the “GHEORGHE ASACHI” TECHNICAL UNIVERSITY OF IASI.

 

We also have an active role in the international scientific community with J. (Koos) F. van Staden serving on the International Advisory Board of Analytical Letters and Journal of Flow Injection Analysis and R. (Raluca) I. van Staden on the International Advisory Board of Preparative Biochemistry and Biotechnology, Sensor Letters and Sensors & Transducers Journal. Both of us are also in a constant process of receiving and refereeing manuscripts from various international journals. J. (Koos) F. van Staden serves on the Steering and Scientific Committee of the 13th International Meeting on Chemical Sensors (IMCS-13) to be held between July 11 – 14, 2010 in Perth, Western Australia and on the steering committee of the 16th International Conference on Flow Injection Analysis, including related techniques(16th ICFIA-2010) to be held between April 25 - 30,2010  at Pattaya , Thailand. Both Koos and Raluca van Staden are active members of the Division of Analytical Chemistry (DAC) of the European Association of Chemical and Molecular Sciences (EuCheMS) and both are also members of the European Association of Chemical and Molecular Sciences (EuCheMS).

 

Professor Dr. Jacobus Frederick van Staden, Professor Emeritus of the University of Pretoria, South Africa and Director of PATLAB, Bucharest, Romania was the Honorary President and Prof Dr Eng. Radu Munteanu, Rector of the Technical University of Cluj-Napoca, Romania the President of the Jury on the occasion of the eighth edition of the International Exhibition of Research, Innovation and Inventions, “PRO INVENT 2010”, organized by the Technical University in collaboration with the Chamber of Commerce and Industry of Romania and the Union Society of Inventors Universities in Cluj,  between 16-19 March 2010 in  Cluj-Napoca, Romania.

 

 

Services offered to end-users:

 

  1. Process analysis in the fields of UV/Vis, Fluorescence, Chemiluminescence, Electrochemistry
  2. Surface Analysis,
  3. Study of biochemical reactions,
  4. Enzymatic Kinetics,
  5. Corrosion,
  6. Deposition and analysis of thin layers

 

THE PRICE OF THE SERVICE WILL BE ESTABLISHED ACCORDINGLY WITH THE SAMPLE AND/OR THE METHOD USED.

 

The application areas of the new SPR are:

  • Biosensors (in combination with amperometry/impedance spectroscopy)
  • Conducting polymers
  • Enzymes
  • Membrane proteins
  • DNA - DNA interactions
  • Protein - virus interactions
  • Peptide - antibody interactions

 

The application areas of the new SECM370 Scanning Electrochemical Microscope system are:

  • Studying flow through membranes
  • Monitoring biologic activity
  • Determining kinetic parameters
  • Imaging immobilized enzymes
  • Monitoring living cells
  • Liquid-liquid interfaces
  • Chemical imaging of biosystems
  • Materials for fuel cell research
  • Localized ISE
  • Surface modification
  • Corrosion science

 

 

PATLAB-Flyer:-

 

The following is the current flyer distributed by PATLAB

 

 

.

 

 

WELCOME to:-

PATLAB

(www.patlab.ro)

the

 PROCESS ANALYTICAL TECHNOLOGY LABORATORY

in BUCHAREST

 

of

 

 

the National Institute of Research and Development for Electrochemistry and Condensed Matter

 

ESTABLISHMENT OF A LABORATORY OF PROCESS ANALYTICAL TECHNOLOGY.

PATLAB

 

Project financed by contract 120 CP/I/14.09.2007

From PN II, Capacity, Module 1

 

 

ESTABLISHMENT OF A LABORATORY OF PROCESS ANALYTICAL TECHNOLOGY. EXTENSION1.

PATLAB-EXTENSION1.

 

Project financed by contract 172 CP/I/02.09.2008

From PN II, Capacity, Module 1

 

Process Analytical Technology (PAT) is the application of Analytical Science in its broadest sense to monitor and control any activity also called operating systems (or processes) as a global entity (in totality) in real-time.

 Micro Process Analytical Technology (MPAT) implies the study and application of PAT with all the available sources and modern microsystems technology.

 Nano Process Analytical Technology (NPAT) implies the study and application of PAT with all the available sources and modern technology on a nano- and even atomic scale.

VISION:- The primary vision is to use PATLAB as a basis and source to supply the necessary skills and education with high quality research and innovation to serve as a catalyst for cost effective dynamic actively driven industries to improve the quality of life and wealth in a sustainable environment. 

MISSION: Research and development in flow-based and non-flow-based systems using PAT and NPAT to create smart intelligent interactive process equipment with highly intelligent interactive built in monitoring and PID control devices to ensure either single-point or multi-point multi-species real-time measurements.

STRATEGY: The strategy of PATLAB, aligned to the national strategy of the R-D-I domain, is to integrate successfully with high level advanced competitive modern instrumentation for research-development as a research laboratory of excellent international status and competence into the new European and national research networks. This should be done in co-operation formed by institutes, universities and economic agents for approach of technological and scientific development programs, that will lead to a social and economical development of our country.

EDUCATION AND TRAINING: It is also my ambition to deliver highly and fully educated specialized young researchers with the necessary skills and dedication to our country to supervise and to keep these systems at end-users in tact and in full operation. Master- and PhD-students (with universities) should feel welcome to use PATLAB with well-equipped facilities as base for their studies to become so well-trained that their expertise should be wanted where-ever they wanted to go, be able to become entrepreneurs to enhance economical development of production and research human potential.

RESEARCH DOMAINS: Process and Nanoprocess analytical technology (PAT and NPAT (on-line, in-line and at-line) for real-time monitoring and small scale synthesis (microreactors and bioreactors) in different fields for example of industrial processes, pharmaceutical manufacturing, agricultural production, health care and medical diagnostics, environmental pollution, leather, paper, ceramic, paints, coatings, textile industries. Research on materials for renewable energy. Research on nanostructures on nano- and atomic scale with high resolution AFM/STM, mini-electrochemical, mini-bioelectrochemical and mini-spectroscopic devices. In this regard, new technologies (including new theoretical foundations and nanotechnologies) on continuous flow, flow injection, sequential injection, sequential flow injection, microfluidics, rotating disc nanotechnology and dot and fiber optic sensors, separation techniques, chromatography (ionic and liquid), capillary electrophoresis, with spectrometric, chemiluminescence, sensors and biosensors as detectors will be developed and implemented

RESEARCH PROJECTS AWARDED THROUGH COMPETITION:-

from the National Plan for Research, Development and Innovation – PN II – Framework of the National Authority for Scientific Research:

CAPACITY PROGRAM – 2007 – Module 1 - PI

Domain 7. Materials, processes and Innovative Production.

ESTABLISHMENT OF A LABORATORY OF PROCESS ANALYTICAL TECHNOLOGY. PATLAB.

CAPACITY PROGRAM – 2008 – Module 1 – P1

Domain 7. Materials, processes and Innovative Production.

ESTABLISHMENT OF A LABORATORY OF PROCESS ANALYTICAL TECHNOLOGY. EXTENSION1. PATLAB-EXTENSION1.

from the National Plan for Research, Development and Innovation – PN II – Framework of the National University Research Council:

IDEA PROGRAM – 2008

Domain 10. Chemical and Process Engineering.

DOT SENSORS. A NEW CONCEPT IN SENSORS TECHNOLOGY.

CURRENT INSTRUMENTATION

1. FLOPRO-FLOW PROCESS RESEARCH ANALYZER.

FlowPro process analyzer configured with two milliGAT pumps, 2 multiposition selection valves, LED-based photometer, heated reactor, process robust computer and software

2. MINI-FLOPRO-ZONE FLUIDICS RESEARCH PROCESS ANALYZER WITH UV/Vis   DETECTION.

Mini-FloPro equipped with milliGAT pump, 2 selection valves, heated reactor and plumbed for zone fluidics equipped to study a variety of chemistries. Ocean Optics multi wavelength spectrometer for UV/vis detection. Laptop PC and process development software.                                                                              

3. MINI-FLOPRO-ZONE FLUIDICS RESEARCH PROCESS ANALYZER. POTENTIOSTAT  FOR AMPEROMETRIC DETECTION

Mini-FloPro equipped with milliGAT pump, 2 selection valves, heated reactor and plumbed for zone fluidics equipped to study a variety of chemistries. Bioanalytical Petit Ampere potentiostat for amperometric detection. Laptop PC and process development software.

4. MINI-FLOPRO-ZONE FLUIDICS RSEARCH PROCESS ANALYZER WITH  FLUORESCENCE DETECTION

Mini-FloPro equipped with milliGAT pump, 2 selection valves, heated reactor and plumbed for zone fluidics equipped to study a variety of chemistries. Ocean Optics detector for fluorescence detection. Laptop PC and process development software.

5. MINI-FLOWPRO-ZONE FLUIDICS RESEARCH PROCESS ANALYZER WITH CHEMILUMINESCENCE DETECTION

Mini-FloPro equipped with milliGAT pump, 2 selection valves, heated reactor and plumbed for zone fluidics equipped to study a variety of chemistries. Global FIA FireFly detector for chemiluminescence detection. Laptop PC and process development software.

6. QE65000 SCIENTIFIC-GRADE SPECTROMETER FOR FLUORESCENCE DETECTION.

QE65000 Scientific-grade Spectrometer, fluorescence setup, PX-2 Pulsed Xenon Lamp as an excitation source, Hamamatsu FFT-CCD detector, detector range 200-1100 nm, Full scans to memory every 7 ms with USB 2.0 port as data transfer rate, Quantum Efficiency to 90%, Optical Fiber Bundles, Computer and software.

7. HR4000 HIGH-RESOLUTION SPECTROMETER.

HR4000 high-resolution spectrometer, UV/Vis through Shortwave NIR setup, Balanced Deuterium Tungsten Source, 3648-element CCD-array detector from Toshiba that enables optical resolution as precise as 0.02 nm (FWHM), detector range 200-1100 nm, Full scans to memory every 4 ms with USB 2.0 port as data transfer rate, Optical Fiber Bundles, Computer and software.

8. UNISCAN PG580 MINI-POTENTIOSTATS (3 UNITS) METROHM AUTOLAB POTENTIOSTATS (3 UNITS) (PGSTAT12, PGSTAT302N and PGSTAT100)

All units suitable for Cyclic and linear voltammetry, Square wave voltammetry, Normal and differential pulse voltammetry Chronoamperometry and chronopotentiometry with micro- and nanosensors, able to bundle up to 5 working electrodes-multiplexed.

9. AGILENT 5500 SERIES ATOMIC FORCE  MICROSCOPY (AFM)/SCANNING  PROBE MICROSCOPY (SPM)

Agilent 5500 ideal multiple-user research system for atomic force microscopy (AFM) and scanning probe microscopy (SPM) with electrochemical scanning microprobe microscopy (EC-SPM) to study the behaviour and kinetics of electrochemical micro- and nanoprobes in real time, Pico-TREC for simultaneous topography and recognition imaging with SPM for mapping target molecules on a sampling surface ideally suited for nanoelectrode sensor structuring and modifying, lithography and nanomanipulation with micro machining through force variations, nano patterning via probe bias and electrochemical etching, nano writing and nano modification via surface potential controlled deposition.

10. SHIMADZU 3600 DOUBLE BEAM UV-VIS-NIR SPECTROPHOTOMETER

High-resolution research spectrometer Wavelength range 185 – 3300 nm, Equipped with 3 detectors: a PMT detector (photomultiplier tube) for the ultraviolet and visible regions, and InGaAs and PbS detectors for near infrared region. InGaAs detector bridges the gap between the PMT - PbS switching wavelength where sensitivity is typically low to ensure high sensitivity over the entire measurement wavelength range with <0.00003 Abs noise at 1500 nm.

11. CYBERSCAN PCD 6500 pH/ION/CONDUCTIVITY/DO MULTIMETER.

Cyberscan PCD 6500  pH/Ion/Conductivity/Dissolved Oxygen multimeter measures and views up to four parameters at the same time with no cross-channel reference. A CE-Driven Full-Colour Touchscreen 21 CFR Part 11-compliant Bench meter with real-time on-screen multichannel, single channel or graphical analysis functions to give quick, convenient analysis of data with advanced, extensive communication capabilities with USB.

12. AUTOLAB ESPRIT SURFACE PLASMA RESONANCE INSTRUMENT.

The Autolab Surface Plasma Resonance (SPR) instrumentation helps the scientist to analyze bi-molecular interactions in real time, without labeling requirements. The Autolab ESPRIT allows the user to perform high-througput SPR experiments using a fully automated system including a reference channel for temperature and non-specific binding compensation. The Autolab Esprit is a unique double channel Surface Plasma Resonance (SPR) instrument with an autosampler incorporated with a normal standard cuvette for all Surface Plasma Resonance (SPR) measurements where biomolecular interactions are studied and a normal cuvette is standard supplied for all SPR measurements where biomolecular interactions are studied. The optional electrochemical cuvette allows measurements on a 3-electrode system: a fixed contact point to the gold layer of the sensor disk, the gold operates as working electrode, replaceable Ag/AgCl reference electrode and a fixed Platinum counter electrode.

13.  SECM370 SCANNING ELECTROCHEMICAL MICROSCOPE SYSTEM.

The SECM370 is a precision scanning micro-electrode system, which can be used to monitor (or impose) current flowing between a micro-electrode and a specimen surface in solution at extremely high spatial resolutions. It can be used to examine, analyse or alter the surface chemistry of a sample in solution. This equipment has many potential applications in the study of fundamentals of surface reactions for example in flow through membranes, chemical imaging of biosystems, corrosion science, or the study of enzyme stabilization. The SECM370 system includes a precision dual potentiostat system, allowing full control and measurement of electrochemical processes at the micro-electrode tip and substrate independently.

CONTACT:- PATLAB. BUCHAREST.

Prof Dr.CS I. J (Koos) F van Staden,

PATLAB,

Process Analytical Technology Laboratory,

Splaiul Independentei St., No 202,

Bucharest. 060021.

ROMANIA.

Mobile: +4 074 169 5743

E-mail: koosvanstaden@yahoo.com